The genetic disorder McCune-Albright syndrome can also present Cushing's syndrome in affected patients. In line with morphometrical studies, both infected group had an. In the adrenal gland, the site of synthesis of cortisol and corticosterone, the zona fasciculata, has been shown to be particularly prone to infection. Steroid-producing adrenal tumours and hyperplasias of the zona fasciculata result in excess cortisol production and are the cause for adrenal Cushing's syndrome. Both zona reticularis and zona fasciculata contained densely packed eosinophilic cells which were not aligned into cords. In certain animals such as rodents, the lack of 17alpha-hydroxylase results in the synthesis of corticosterone instead of cortisol. This tissue also generates a small amount of weak androgens. The zona fasciculata chiefly produces glucocorticoids (mainly cortisol in the human), which regulates the metabolism of glucose, especially in times of stress (e.g. The cells of the zona fasciculata lie in parallel radial cords, and the name stems originally from the Roman symbol of office, the fasces or bundle of birch. Constituent cells are organized into bundles or 'fascicles'. The zona fasciculata constitutes the middle zone of the adrenal cortex, sitting directly beneath the zona glomerulosa. The cells of the zona fasciculata have considerably more cytoplasm than those of the other cortical zones and stain. zona fasciculata of suprarenal gland (exact synonym, ).adrenal gland zona fasciculata (exact synonym, ).
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